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KMID : 0608520110170020129
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Korean Journal of Oriental Medicine
2011 Volume.17 No. 2 p.129 ~ p.134
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Effects of Carthami Flos on Human Colorectal Adenocarcinoma Cells
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Han Song-Ee
Kim Jung-A
Song Ho-Joon
Chae Han
Kwon Young-Kyu
Kim Byung-Joo
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Abstract
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Objective : The purpose of this study was to investigate the anti-cancer effects of Carthami Flos in some kinds of human colorectal adenocarcinoma cells.
Method: We used two kinds of human colorectal adenocarcinoma cell lines, such as HT-29 and WiDr cells. We examined cell death by MTT assay and observed the morphological changes with Carthami Flos.
Result: We showed that the combination of sub-optimal doses of Carthami Flos and cisplatin noticeably suppresses in HT-29 cells and doxorubicin in WiDr cells. Furthermore, we studied the caspase 3 activity to identify the apoptosis.
Conclusion: Our findings provide insight into unraveling the effects of Carthami Flos in human colorectal adenocarcinoma cells and developing therapeutic agents against colorectal cancer.
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KEYWORD
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Carthami Flos, Human Colorectal Adenocarcinoma Cell, HT-29, WiDr
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